An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

Nuclear factor kappa B p50 (NF-B p50) induces various biological processes. In this study, a highly selective and sensitive electrochemiluminescence (ECL) biosensor for the detection of NF-B p50 has been developed, which combines the high selectivity of the proximity hybridization assay (PHA) with t...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (86), p.1298-12983
Hauptverfasser: Huang, Xiaocui, Zhang, Ying, Xu, Wen, Xu, Wei, Guo, Longhua, Qiu, Bin, Lin, Zhenyu
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Biosensors
Chain reactions (nuclear physics)
Electrochemiluminescence
Hybridization
Selectivity
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Zusammenfassung:Nuclear factor kappa B p50 (NF-B p50) induces various biological processes. In this study, a highly selective and sensitive electrochemiluminescence (ECL) biosensor for the detection of NF-B p50 has been developed, which combines the high selectivity of the proximity hybridization assay (PHA) with the high efficiency of the hybridization chain reaction (HCR). Nuclear factor kappa B p50 (NF-B p50) induces various biological processes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc06210f