Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe
Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (67), p.9919-9922 |
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| container_end_page | 9922 |
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| container_issue | 67 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 55 |
| creator | Chen, Yefeng Xu, Minqiu Xu, Weipan Song, Heng Hu, Liqiang Xue, Shuyuan Zhang, Shuangzhan Qian, Xiana Xie, Hexin |
| description | Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.
An unprecedented relebactam-based fluorogenic probe is reported for the wash-free imaging of resistant bacteria. |
| doi_str_mv | 10.1039/c9cc04533c |
| format | Article |
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An unprecedented relebactam-based fluorogenic probe is reported for the wash-free imaging of resistant bacteria.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c9cc04533c</identifier><identifier>PMID: 31328197</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Affinity Labels - chemical synthesis ; Affinity Labels - chemistry ; Affinity Labels - pharmacology ; Amides ; Antibiotics ; Azabicyclo Compounds - chemical synthesis ; Azabicyclo Compounds - chemistry ; Azabicyclo Compounds - pharmacology ; Bacteria ; beta-Lactamase Inhibitors - chemical synthesis ; beta-Lactamase Inhibitors - chemistry ; beta-Lactamase Inhibitors - pharmacology ; beta-Lactamases - chemistry ; Bonding strength ; Enterobacter cloacae - enzymology ; Enterobacter cloacae - isolation & purification ; Fluoresceins - chemical synthesis ; Fluoresceins - chemistry ; Fluoresceins - pharmacology ; Fluorescence ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - pharmacology ; Indoles - chemical synthesis ; Indoles - chemistry ; Indoles - pharmacology ; Reagents ; Visualization</subject><ispartof>Chemical communications (Cambridge, England), 2019-08, Vol.55 (67), p.9919-9922</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-452c336e1a5c6dad113accfbac4a45ebe46943c53114f79cb04973e7b121ab663</citedby><cites>FETCH-LOGICAL-c363t-452c336e1a5c6dad113accfbac4a45ebe46943c53114f79cb04973e7b121ab663</cites><orcidid>0000-0003-1033-9211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31328197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yefeng</creatorcontrib><creatorcontrib>Xu, Minqiu</creatorcontrib><creatorcontrib>Xu, Weipan</creatorcontrib><creatorcontrib>Song, Heng</creatorcontrib><creatorcontrib>Hu, Liqiang</creatorcontrib><creatorcontrib>Xue, Shuyuan</creatorcontrib><creatorcontrib>Zhang, Shuangzhan</creatorcontrib><creatorcontrib>Qian, Xiana</creatorcontrib><creatorcontrib>Xie, Hexin</creatorcontrib><title>Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.
An unprecedented relebactam-based fluorogenic probe is reported for the wash-free imaging of resistant bacteria.</description><subject>Affinity Labels - chemical synthesis</subject><subject>Affinity Labels - chemistry</subject><subject>Affinity Labels - pharmacology</subject><subject>Amides</subject><subject>Antibiotics</subject><subject>Azabicyclo Compounds - chemical synthesis</subject><subject>Azabicyclo Compounds - chemistry</subject><subject>Azabicyclo Compounds - pharmacology</subject><subject>Bacteria</subject><subject>beta-Lactamase Inhibitors - chemical synthesis</subject><subject>beta-Lactamase Inhibitors - chemistry</subject><subject>beta-Lactamase Inhibitors - pharmacology</subject><subject>beta-Lactamases - chemistry</subject><subject>Bonding strength</subject><subject>Enterobacter cloacae - enzymology</subject><subject>Enterobacter cloacae - isolation & purification</subject><subject>Fluoresceins - chemical synthesis</subject><subject>Fluoresceins - chemistry</subject><subject>Fluoresceins - pharmacology</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - pharmacology</subject><subject>Indoles - chemical synthesis</subject><subject>Indoles - chemistry</subject><subject>Indoles - pharmacology</subject><subject>Reagents</subject><subject>Visualization</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFr3DAQhUVoSdK0l9xbFHopBbeWR5KtYzBtUwj0kkJvZjweZxW89layNyS_vtpsmkAP1WXEvI83wzwhTlX-SeXgPpMjyrUBoANxrMDqzOjq14vd37isBG2OxKsYb_L0lKkOxREoKCrlymMxXvjr1XAnIw9Ms9-yxLGTtxhXWR-Y5dbHBQd_j7OfRjn1MnD0ccZxli3SzMGjvPXzSmJSBt71cJ11qb_lTvbDMoXpmkdPchOmll-Llz0Okd881hPx8-uXq_oiu_zx7Xt9fpkRWJgzbQoCsKzQkO2wUwqQqE_uGrXhlrV1GsiAUrovHbW5diVw2apCYWstnIgPe9809ffCcW7WPhIPA448LbEpCqtclVunEvr-H_RmWsKYtktUmSZUeVEl6uOeojDFGLhvNsGvMdw1Km92KTS1q-uHFOoEv3u0XNo1d0_o37Mn4O0eCJGe1OcYk372P73ZdD38ATlKmJo</recordid><startdate>20190828</startdate><enddate>20190828</enddate><creator>Chen, Yefeng</creator><creator>Xu, Minqiu</creator><creator>Xu, Weipan</creator><creator>Song, Heng</creator><creator>Hu, Liqiang</creator><creator>Xue, Shuyuan</creator><creator>Zhang, Shuangzhan</creator><creator>Qian, Xiana</creator><creator>Xie, Hexin</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1033-9211</orcidid></search><sort><creationdate>20190828</creationdate><title>Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe</title><author>Chen, Yefeng ; Xu, Minqiu ; Xu, Weipan ; Song, Heng ; Hu, Liqiang ; Xue, Shuyuan ; Zhang, Shuangzhan ; Qian, Xiana ; Xie, Hexin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-452c336e1a5c6dad113accfbac4a45ebe46943c53114f79cb04973e7b121ab663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Affinity Labels - chemical synthesis</topic><topic>Affinity Labels - chemistry</topic><topic>Affinity Labels - pharmacology</topic><topic>Amides</topic><topic>Antibiotics</topic><topic>Azabicyclo Compounds - chemical synthesis</topic><topic>Azabicyclo Compounds - chemistry</topic><topic>Azabicyclo Compounds - pharmacology</topic><topic>Bacteria</topic><topic>beta-Lactamase Inhibitors - chemical synthesis</topic><topic>beta-Lactamase Inhibitors - chemistry</topic><topic>beta-Lactamase Inhibitors - pharmacology</topic><topic>beta-Lactamases - chemistry</topic><topic>Bonding strength</topic><topic>Enterobacter cloacae - enzymology</topic><topic>Enterobacter cloacae - isolation & purification</topic><topic>Fluoresceins - chemical synthesis</topic><topic>Fluoresceins - chemistry</topic><topic>Fluoresceins - pharmacology</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent Dyes - pharmacology</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - chemistry</topic><topic>Indoles - pharmacology</topic><topic>Reagents</topic><topic>Visualization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yefeng</creatorcontrib><creatorcontrib>Xu, Minqiu</creatorcontrib><creatorcontrib>Xu, Weipan</creatorcontrib><creatorcontrib>Song, Heng</creatorcontrib><creatorcontrib>Hu, Liqiang</creatorcontrib><creatorcontrib>Xue, Shuyuan</creatorcontrib><creatorcontrib>Zhang, Shuangzhan</creatorcontrib><creatorcontrib>Qian, Xiana</creatorcontrib><creatorcontrib>Xie, Hexin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yefeng</au><au>Xu, Minqiu</au><au>Xu, Weipan</au><au>Song, Heng</au><au>Hu, Liqiang</au><au>Xue, Shuyuan</au><au>Zhang, Shuangzhan</au><au>Qian, Xiana</au><au>Xie, Hexin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2019-08-28</date><risdate>2019</risdate><volume>55</volume><issue>67</issue><spage>9919</spage><epage>9922</epage><pages>9919-9922</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.
An unprecedented relebactam-based fluorogenic probe is reported for the wash-free imaging of resistant bacteria.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31328197</pmid><doi>10.1039/c9cc04533c</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-1033-9211</orcidid></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2019-08, Vol.55 (67), p.9919-9922 |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Affinity Labels - chemical synthesis Affinity Labels - chemistry Affinity Labels - pharmacology Amides Antibiotics Azabicyclo Compounds - chemical synthesis Azabicyclo Compounds - chemistry Azabicyclo Compounds - pharmacology Bacteria beta-Lactamase Inhibitors - chemical synthesis beta-Lactamase Inhibitors - chemistry beta-Lactamase Inhibitors - pharmacology beta-Lactamases - chemistry Bonding strength Enterobacter cloacae - enzymology Enterobacter cloacae - isolation & purification Fluoresceins - chemical synthesis Fluoresceins - chemistry Fluoresceins - pharmacology Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Reagents Visualization |
| title | Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe |
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