photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis

We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine de...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (65), p.9685-9688
Hauptverfasser: Wang, Hui, Zhang, Yixin, Yang, Yuyun, He, Zixu, Wu, Chuanchen, Zhang, Wei, Zhang, Wen, Liu, Ju, Li, Ping, Tang, Bo
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container_end_page 9688
container_issue 65
container_start_page 9685
container_title Chemical communications (Cambridge, England)
container_volume 55
creator Wang, Hui
Zhang, Yixin
Yang, Yuyun
He, Zixu
Wu, Chuanchen
Zhang, Wei
Zhang, Wen
Liu, Ju
Li, Ping
Tang, Bo
description We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine deficiency. In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis.
doi_str_mv 10.1039/c9cc03814k
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title photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis
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