photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis

We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (65), p.9685-9688
Hauptverfasser:	Wang, Hui, Zhang, Yixin, Yang, Yuyun, He, Zixu, Wu, Chuanchen, Zhang, Wei, Zhang, Wen, Liu, Ju, Li, Ping, Tang, Bo
Format:	Artikel
Sprache:
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We developed a photoacoustic and fluorescent dual-mode imaging probe, CCYS, for the detection of cysteine with high selectivity and sensitivity in a living system for the first time. By using CCYS, we found that the limited synthesis of glutathione in pulmonary fibrosis was not caused by cysteine deficiency. In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c9cc03814k