pH-sensitive loaded retinal/indocyanine green micelles as an "all-in-one" theranostic agent for multi-modal imaging guided cellular senescence-photothermal synergistic therapy

In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed to realize novel approaches for cellular senescence-photothermal synergistic therapy to treat cancer. The micelles could enable effective multi-modal imaging in vivo guided therapy and show anticancer activity in vitro and in vivo with satisfactory biosafety. pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed for cellular senescence-photothermal synergistic therapy.