A thermoresponsive nanocarrier for mitochondria-targeted drug delivery
Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer c...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (28), p.451-454 |
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| container_end_page | 454 |
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| container_issue | 28 |
| container_start_page | 451 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 55 |
| creator | Wang, Dongqing Huang, Hui Zhou, Mengxue Lu, Huiru Chen, Jun Chang, Young-Tae Gao, Jimin Chai, Zhifang Hu, Yi |
| description | Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery. |
| doi_str_mv | 10.1039/c9cc00603f |
| format | Article |
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A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c9cc00603f</identifier><identifier>PMID: 30870553</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Cancer ; Cell Line ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Dose-Response Relationship, Drug ; Drug Carriers - chemistry ; Drug delivery systems ; Drug Screening Assays, Antitumor ; High temperature ; Humans ; Mice ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - metabolism ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Neoplasms - pathology ; Paclitaxel - administration & dosage ; Paclitaxel - pharmacology ; Structure-Activity Relationship ; Temperature ; Temperature dependence</subject><ispartof>Chemical communications (Cambridge, England), 2019-04, Vol.55 (28), p.451-454</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-d3767166b0a1d84252e326e816ef118bcf950f368c6840cb87b0307b2512a013</citedby><cites>FETCH-LOGICAL-c403t-d3767166b0a1d84252e326e816ef118bcf950f368c6840cb87b0307b2512a013</cites><orcidid>0000-0002-0952-0657 ; 0000-0002-1927-3688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30870553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Dongqing</creatorcontrib><creatorcontrib>Huang, Hui</creatorcontrib><creatorcontrib>Zhou, Mengxue</creatorcontrib><creatorcontrib>Lu, Huiru</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Chang, Young-Tae</creatorcontrib><creatorcontrib>Gao, Jimin</creatorcontrib><creatorcontrib>Chai, Zhifang</creatorcontrib><creatorcontrib>Hu, Yi</creatorcontrib><title>A thermoresponsive nanocarrier for mitochondria-targeted drug delivery</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery systems</subject><subject>Drug Screening Assays, Antitumor</subject><subject>High temperature</subject><subject>Humans</subject><subject>Mice</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>Paclitaxel - administration & dosage</subject><subject>Paclitaxel - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>Temperature</subject><subject>Temperature dependence</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0cFLwzAUBvAgipvTi3el4EWE6kvSpOlxFKfCwMsO3kqapltH28yXVth_b-fmBHNJIL98PL4Qck3hkQJPnkxiDIAEXp6QMeUyCkWkPk53Z5GEMY_EiFx4v4ZhUaHOyYiDikEIPiazadCtLDYOrd-41ldfNmh164xGrCwGpcOgqTpnVq4tsNJhp3FpO1sEBfbLoLD18AK3l-Ss1LW3V4d9Qhaz50X6Gs7fX97S6Tw0EfAuLHgsYyplDpoWKmKCWc6kVVTaklKVmzIRUHKpjFQRmFzFOXCIcyYo00D5hNzvYzfoPnvru6ypvLF1rVvrep8xmvAhXkE80Lt_dO16bIfhMsaAKRpxkIN62CuDznu0ZbbBqtG4zShku3KzNEnTn3JnA749RPZ5Y4sj_W1zADd7gN4cb_9-h38DiqJ80A</recordid><startdate>20190402</startdate><enddate>20190402</enddate><creator>Wang, Dongqing</creator><creator>Huang, Hui</creator><creator>Zhou, Mengxue</creator><creator>Lu, Huiru</creator><creator>Chen, Jun</creator><creator>Chang, Young-Tae</creator><creator>Gao, Jimin</creator><creator>Chai, Zhifang</creator><creator>Hu, Yi</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0952-0657</orcidid><orcidid>https://orcid.org/0000-0002-1927-3688</orcidid></search><sort><creationdate>20190402</creationdate><title>A thermoresponsive nanocarrier for mitochondria-targeted drug delivery</title><author>Wang, Dongqing ; Huang, Hui ; Zhou, Mengxue ; Lu, Huiru ; Chen, Jun ; Chang, Young-Tae ; Gao, Jimin ; Chai, Zhifang ; Hu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-d3767166b0a1d84252e326e816ef118bcf950f368c6840cb87b0307b2512a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery systems</topic><topic>Drug Screening Assays, Antitumor</topic><topic>High temperature</topic><topic>Humans</topic><topic>Mice</topic><topic>Mitochondria</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>Paclitaxel - administration & dosage</topic><topic>Paclitaxel - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>Temperature</topic><topic>Temperature dependence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Dongqing</creatorcontrib><creatorcontrib>Huang, Hui</creatorcontrib><creatorcontrib>Zhou, Mengxue</creatorcontrib><creatorcontrib>Lu, Huiru</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Chang, Young-Tae</creatorcontrib><creatorcontrib>Gao, Jimin</creatorcontrib><creatorcontrib>Chai, Zhifang</creatorcontrib><creatorcontrib>Hu, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Dongqing</au><au>Huang, Hui</au><au>Zhou, Mengxue</au><au>Lu, Huiru</au><au>Chen, Jun</au><au>Chang, Young-Tae</au><au>Gao, Jimin</au><au>Chai, Zhifang</au><au>Hu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A thermoresponsive nanocarrier for mitochondria-targeted drug delivery</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2019-04-02</date><risdate>2019</risdate><volume>55</volume><issue>28</issue><spage>451</spage><epage>454</epage><pages>451-454</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30870553</pmid><doi>10.1039/c9cc00603f</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-0952-0657</orcidid><orcidid>https://orcid.org/0000-0002-1927-3688</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2019-04, Vol.55 (28), p.451-454 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Cancer Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Drug Carriers - chemistry Drug delivery systems Drug Screening Assays, Antitumor High temperature Humans Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - pathology Paclitaxel - administration & dosage Paclitaxel - pharmacology Structure-Activity Relationship Temperature Temperature dependence |
| title | A thermoresponsive nanocarrier for mitochondria-targeted drug delivery |
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