A thermoresponsive nanocarrier for mitochondria-targeted drug deliveryElectronic supplementary information (ESI) available: Experimental section, and supporting figures. See DOI: 10.1039/c9cc00603f

Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy. A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery.