Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generationElectronic supplementary information (ESI) available. See DOI: 10.1039/c8re00039e

A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf 2 NH-amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etherification-(2 + 2) cycloaddition reaction were demonstrated. A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf 2 NH-amine co-catalyst under mild conditions has been developed.