Highly stereoselective spirocyclopropanation of various diazooxindoles with olefins catalyzed using Ru()-complex

Highly stereoselective spirocyclopropanation of various diazooxindoles with olefins catalyzed using Ru()-complex

Optically active spirocyclopropyloxindole derivatives were efficiently synthesized from diazooxindoles and olefins in the presence of a Ru( ii )-Pheox catalyst. Among a series of Ru( ii )-Pheox catalysts, Ru( ii )-Pheox 6e was determined to be the best catalyst for spirocyclopropanation reactions of...

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Veröffentlicht in:RSC advances 2018-11, Vol.8 (7), p.39865-39869
Hauptverfasser: Tone, Masaya, Nakagawa, Yoko, Chanthamath, Soda, Fujisawa, Ikuhide, Nakayama, Naofumi, Goto, Hitoshi, Shibatomi, Kazutaka, Iwasa, Seiji
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Catalysis
Catalysts
Chemical synthesis
Chemistry
Crystallography
Optical activity
Stereoselectivity
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Zusammenfassung:Optically active spirocyclopropyloxindole derivatives were efficiently synthesized from diazooxindoles and olefins in the presence of a Ru( ii )-Pheox catalyst. Among a series of Ru( ii )-Pheox catalysts, Ru( ii )-Pheox 6e was determined to be the best catalyst for spirocyclopropanation reactions of diazooxindoles with various olefins in high yields (up to 98%) with high diastereoselectivities (up to trans : cis = >99:1
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra09212e