Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group

Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group

The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm. P...

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Veröffentlicht in:RSC advances 2019-01, Vol.9 (1), p.166-171
Hauptverfasser: Goto, Yuya, Ueda, Masafumi, Sugikawa, Kouta, Yasuhara, Kazuma, Ikeda, Atsushi
Format: Artikel
Sprache:eng
Schlagworte:
Absorption spectra
Antibiotics
Chemistry
Drug delivery systems
Hydrophobicity
Lipids
Liposomes
NMR
Nuclear magnetic resonance
Penicillin
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Zusammenfassung:The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm. Penicillin G as an antibiotic was released from liposomes by increase of hydrophilicity by photocleavage of a hydrophobic protecting group.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra08584f