Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platformsElectronic supplementary information (ESI) available. CCDC 1858311. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ra06494f

Several 2-arylcinnolin-6(2 H )-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors affecting the optimization of the annulation process were thoroughly studied. The annulated structures were established on the basis of 1 H and 13 C NMR and MALDI-TOF/MS spectral data as well as single crystal X-ray analysis. Several 2-arylcinnolin-6(2 H )-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes.