Targeting HMGA protein inhibits retinoblastoma cell proliferationElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ra06026f

Targeting HMGA protein inhibits retinoblastoma cell proliferationElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ra06026f

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells. A novel approach to target HMGA proteins in retinob...

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Hauptverfasser: Balachandran, Akilandeswari, Zambre, Ajit, Kainth, Jagjot Singh, Nagarajha Selvan, Lakshmi Dhevi, Parameswaran, Sowmya, Afrasiabi, Zahra, Krishnakumar, Subramanian, Kannan, Raghuraman, Upendran, Anandhi
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Sprache:eng
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Zusammenfassung:We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells. A novel approach to target HMGA proteins in retinoblastoma using HMGA2 siRNA-nucleolin aptamer and HMGA aptamer-nucleolin antibody conjugates was developed.
ISSN:2046-2069
DOI:10.1039/c8ra06026f