Synthesis of α-amino ketones through aminations of umpoled enolatesElectronic supplementary information (ESI) available: Detailed experimental procedures and copies of NMR spectra. See DOI: 10.1039/c8ob02004c

An efficient synthesis of α-amino ketones is developed using the umpolung strategy. Umpoled enolates such as N -alkenoxypyridinium salts react smoothly with diverse amines to give α-amino ketones via an S N 2′ pathway. This umpolung strategy overcomes the drawbacks of traditional methods such as the need for prefunctionalized ketone derivatives. Our method also offers good chemical yields and high functional group tolerance. An efficient synthesis of α-amino ketones is developed using the umpolung strategy.