Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamatesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob01059e

An electrochemical Hofmann rearrangement is reported. With the mediation of NaBr, highly corrosive and toxic halogens are avoided. Moreover, this efficient and green approach is well compatible with a broad range of amides, including several commercial medicine derivatives, and provides direct access to synthetically useful carbamates. The synthetic utility of this method is also demonstrated by the preparation of 15 N labeling carbamate and gram-scale synthesis of Amantadine. An electrochemical Hofmann rearrangement is reported, which provides general and practical access to bioactive carbamates.