A convergent strategy towards febrifugine and related compoundsElectronic supplementary information (ESI) available. CCDC 1450620. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ob00935j

We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs. We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups.