NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenesElectronic supplementary information (ESI) available. CCDC 1562256 and 1547136. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8nj02756k

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1 H -azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products. We have developed a useful and simple process for the NaOH-promoted reaction of 1,1-dihaloalkenes and 1 H -azoles to afford dipyrazolyl alkenes under mild and transition-metal-free conditions.