UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b]quinoline-2,4-diones in aqueous-glycerol mediumElectronic supplementary information (ESI) available. See DOI: 10.1039/c8nj01459k

Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5- b ]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV 365 light source in the absence of a photocatalyst. The reported approach has several advantages such as high yield, clean reaction conditions, chromatography-free synthesis and the use of a cheap water-glycerol solvent system, which is also an environmentally friendly solvent. The applicability of this protocol for the large-scale synthesis of pyrimido[4,5- b ]quinolinone-2,4-diones without wasting any expensive chemicals is an added advantage. Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5- b ]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported.