Synthesis of a deoxyguanosine monophosphate rich propyl methacrylate oligomerElectronic supplementary information (ESI) available. See DOI: 10.1039/c8nj00989a

We report on the first synthesis of a "protected" 5′-dimethoxytrityl- N -isobutyryl-2′-deoxyguanosine(dG), 3′-[(2-cyanoethyl)-2-(methacryloyloxy)propyl]-monophosphate monomer through a modified phosphoramidite coupling method. Here, 2-hydroxylpropyl methacrylate (HPMA) was coupled to a protected 5′-dimethoxytrityl- N -isobutyryl-2′-deoxyguanosine, 3′-[(2-cyanoethyl)-( N , N -diisopropyl)]-phosphoramidite. Subsequent reversible addition fragmentation chain transfer (RAFT) polymerisation of the protected monomer, followed by deprotection, produced poly[2-(deoxyguanosine-3′-phospho)propyl methacrylate] (poly(dG-P-PMA)). In situ 1 H nuclear magnetic resonance spectroscopy showed the polymerisation kinetics were consistent with RAFT with dispersity indices ( 's)