Application of molecularly imprinted polymer nanoparticles for degradation of the bacterial autoinducer -hexanoyl homoserine lactone

A novel bacterial quorum quenching system is presented. For the first time the degradation of N - l -hexanoyl homoserine lactone (C6-AHL), a Gram-negative quorum sensing autoinducer, has been enhanced using molecularly imprinted nanoparticles (MIP NPs) which were prepared using transition state analogue of the γ-lactone ring hydrolysis as template. A novel bacterial quorum quenching system is presented.