One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C-H bond difunctionalization and C-N bond cleavageElectronic supplementary information (ESI) available: Experimental details and spectroscopic data. CCDC 1855990. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8cc06946h

TBN-initiated cascade multifunctionalization of inert C-H and C-N bonds in N -arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N-NO and aldehyde functional groups were constructed in only one synthetic step. TBN initiated α,β-sp 3 C-H bond difunctionalization and C-N bond cleavage have been realized.