Turning off quorum sensing system with peptidic analogs

We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus . We generated PapR 7 -peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus . We designed and synthesized B. cereus PlcR-PapR quorum sensing peptidic inhibitors.