Highly enantioselective Friedel-Crafts alkylation of ,-dialkylanilines with -β-nitrostyrene catalyzed by a homochiral metal-organic framework

The first enantioselective Friedel-Crafts alkylation of N , N -dialkylanilines with trans -β-nitrostyrene catalyzed by a homochiral metal-organic framework constructed from ( R )-2,2′-dihydroxy-1,1′-binaphthyl-6,6′-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee). The first enantioselective Friedel-Crafts alkylation of N , N -dialkylanilines with trans -β-nitrostyrene catalyzed by a homochiral MOF afforded the addition products in high yields (∼96%) with excellent ee (∼98%).