Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates. Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic.