Facile synthesis of novel hybrid POSS biomolecules via "Click" reactionsElectronic supplementary information (ESI) available: Detailed experimental procedures, 1H, 13C, 19F, 29Si NMR, IR, MALDI-TOF MS, elemental analysis, and analytical data for all new compounds. For ESI and crystallographic data in CIF or other electronic format. CCDC 1514595. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ra07915j

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82-90%). The X-ray crystal structure revealed intra- and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido- N -Fmoc-norleucine and (ii) 3′-azido-3′-deoxythymidine. A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield and click chemistry has been used to attach bio-oligomers.