Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loadingElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nr05935c

Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL −1 . The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity. Polyphosphoester-based nanoparticles are capable of loading paclitaxel chemically and physically, achieving ultrahigh equivalent paclitaxel aqueous concentrations.