MicroRNA detection at femtomolar concentrations with isothermal amplification and a biological nanoporeElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nr04215a

One of the greatest challenges faced by chemists and biologists is the detection of molecules at extremely low concentrations. This paper describes a method to detect ultra-low concentrations (1 femtomole) of nucleotides using isothermal amplification and a biological nanopore. This paper describes a method to detect ultra-low concentrations of nucleotides using isothermal amplification and a biological nanopore.