Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydrationElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ce00826k

We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid. The dehydration of cocrystals of macro-dimensions results in destruction of crystal morphology; however, crystal morphology is retained when the cocrystal is reduced to nanometer-dimensions, despite a lack of pores to accommodate loss of water. We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid.