Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagonElectronic supplementary information (ESI) available: Experimental details regarding the synthesis and characterization of 1, 3, 5, and 9, cell culture, the MTT assay, cellular uptake, real-time PCR, flow cytometry, and HPLC analysis are presented. See DOI: 10.1039/c7cc07622c

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt( iv ) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines. A supramolecular hexagon obtained from coordination-driven self-assembly can be used to deliver platinum-based anticancer agents and promote their therapeutic index.