Assembly of the active center of organophosphorus hydrolase in metal-organic frameworks rational combination of functional ligands

Different from popular mimics of bimetallic nuclear centers bridged by a hydroxide, a total coordination sphere of the active center of organophosphorus hydrolase was assembled in metal-organic frameworks by rational design and combination of ligands, which resulted in efficient destruction of nerve agent stimulants without a base as a co-catalyst. Mimicking the total coordination sphere of the active center of organophosphorus hydrolase in MOFs to destruct nerve agents without co-catalysts.