A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behaviorThis is manuscript # 29497 from the Scripps Research Institute.Electronic supplementary information (ESI) available: Materials and methods, supplementary and extended figures. See DOI: 10.1039/c7cc04055e

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg −1 with superior efficacy compared to a standard conjugate. A bioconjugate targeted to prefromed, xenoreactive antibodies also containing a cocaine hapten elicits a potent and specific anti-cocaine response able to significantly attenuate cocaine-induced behavior.