A targeted delivery strategy for the development of potent trypanocidesElectronic supplementary information (ESI) available: Full experimental details and physical data for all new compounds. See DOI: 10.1039/c7cc03378h

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei , the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequ...

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Hauptverfasser:	Gordhan, Heeren M, Milanes, Jillian E, Qiu, Yijian, Golden, Jennifer E, Christensen, Kenneth A, Morris, James C, Whitehead, Daniel C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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