A targeted delivery strategy for the development of potent trypanocidesElectronic supplementary information (ESI) available: Full experimental details and physical data for all new compounds. See DOI: 10.1039/c7cc03378h

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei , the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite. A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei , the causative agent of African sleeping sickness.