Chiral N,N′-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide sourceElectronic supplementary information (ESI) available: Additional experimental and spectroscopic data. CCDC 1503924. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7cc00470b

The catalytic asymmetric bromoamination of chalcones with N -bromosuccinimide as both bromine and amide source was realized by using a chiral N , N ′-dioxide-Sc(NTf 2 ) 3 complex as an efficient catalyst. The corresponding chiral bromoamination products were obtained in high yields with high dr and good ee values (up to 92% yield, 93 : 7 dr and 97% ee) under mild reaction conditions. A chiral N , N ′-dioxide-Sc(NTf 2 ) 3 complex catalytic system has been developed to catalyze the asymmetric bromoamination reaction of chalones with N -bromosuccinimide.