Biologically active γ-lactams: synthesis and natural sources

The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities. This review surveys the different synthetic and natural sources of biologically active γ-lactam compounds.