Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams
A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described. A method for the pa...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2016-08, Vol.14 (32), p.7731-7734 |
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| container_end_page | 7734 |
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| container_issue | 32 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Canterbury, Daniel P Hesp, Kevin D Polivkova, Jana |
| description | A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.
A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. |
| doi_str_mv | 10.1039/c6ob01126h |
| format | Article |
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A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported.</description><subject>Catalysis</subject><subject>Hydrocarbons, Brominated - chemical synthesis</subject><subject>Hydrocarbons, Brominated - chemistry</subject><subject>Lactams - chemistry</subject><subject>Molecular Structure</subject><subject>Palladium - chemistry</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1KAzEUBeAgiq3VjXulyyqOJpP_pRa1YqEudD0kmQwdmenUJFOob6UP0mcy2lq3rhK4HxfOuQAcI3iJIJZXhjUaIpSy6Q7oIsJ5AimWu9t_CjvgwPtXCJHkjOyDTsoJQ5zKLnh8UlWl8rKtE6OCqpbvNu-vPpPB1AbrmjPllpUKZTPrN0V_9XERR-3Mq9A6FaJcqCqqSpmgan8I9gpVeXu0eXvg5e72eThKxpP7h-H1ODGYpCFhpjAU5RBrTTQqpLAMIcxSLDDFotDQIsJsjrEgLOUUas6JlVjHrLnSUuEeGKz3zl3z1lofsrr0xsYcM9u0PkMCUQ4lS-l_KBRMMCoiPV9T4xrvnS2yuSvrmD9DMPvuORuyyc1Pz6OITzd7W13bfEt_i43gZA2cN9vp36HwFyfZgzU</recordid><startdate>20160810</startdate><enddate>20160810</enddate><creator>Canterbury, Daniel P</creator><creator>Hesp, Kevin D</creator><creator>Polivkova, Jana</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160810</creationdate><title>Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams</title><author>Canterbury, Daniel P ; Hesp, Kevin D ; Polivkova, Jana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-6cfc51d03bb4b1f98e611362383538fb0e146ed338462750b774e93b103dab9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Catalysis</topic><topic>Hydrocarbons, Brominated - chemical synthesis</topic><topic>Hydrocarbons, Brominated - chemistry</topic><topic>Lactams - chemistry</topic><topic>Molecular Structure</topic><topic>Palladium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canterbury, Daniel P</creatorcontrib><creatorcontrib>Hesp, Kevin D</creatorcontrib><creatorcontrib>Polivkova, Jana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canterbury, Daniel P</au><au>Hesp, Kevin D</au><au>Polivkova, Jana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2016-08-10</date><risdate>2016</risdate><volume>14</volume><issue>32</issue><spage>7731</spage><epage>7734</epage><pages>7731-7734</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2016-08, Vol.14 (32), p.7731-7734 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Catalysis Hydrocarbons, Brominated - chemical synthesis Hydrocarbons, Brominated - chemistry Lactams - chemistry Molecular Structure Palladium - chemistry |
| title | Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams |
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