Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition

Triazole-linked morpholino ( TL MO) oligonucleic acids were synthesised using the Cu I catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TL MO modificatio...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-03, Vol.14 (11), p.3112-3119
Hauptverfasser:	Palframan, Matthew J, Alharthy, Rima D, Powalowska, Paulina K, Hayes, Christopher J
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