Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition
Triazole-linked morpholino ( TL MO) oligonucleic acids were synthesised using the Cu I catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TL MO modificatio...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2016-03, Vol.14 (11), p.3112-3119 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Palframan, Matthew J Alharthy, Rima D Powalowska, Paulina K Hayes, Christopher J |
| description | Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences
via
solid phase synthesis. UV melting experiments showed that the
TL
MO modification gives higher
T
m
values than the corresponding
TL
DNA modification.
Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. |
| doi_str_mv | 10.1039/c6ob00007j |
| format | Article |
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TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences
via
solid phase synthesis. UV melting experiments showed that the
TL
MO modification gives higher
T
m
values than the corresponding
TL
DNA modification.
Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c6ob00007j</identifier><ispartof>Organic & biomolecular chemistry, 2016-03, Vol.14 (11), p.3112-3119</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Palframan, Matthew J</creatorcontrib><creatorcontrib>Alharthy, Rima D</creatorcontrib><creatorcontrib>Powalowska, Paulina K</creatorcontrib><creatorcontrib>Hayes, Christopher J</creatorcontrib><title>Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition</title><title>Organic & biomolecular chemistry</title><description>Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences
via
solid phase synthesis. UV melting experiments showed that the
TL
MO modification gives higher
T
m
values than the corresponding
TL
DNA modification.
Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction.</description><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFTr0OgjAYbIwm4s_ibtIXQIsghJlo3HUntRQpln6kXxnw6e1gdPSG-8ndcIRsIraLWJzvRQp35pG1ExJESZaF7Bjn068_sDlZILaMRXmWJgG5XkfjGokKKdTUWcVfoGWolXnKinZg-wZ8AOr5AWYQWoJTlURaDFRwx_WIfihGoYFXlXIKzIrMaq5Rrj-6JNvz6VZcQoui7K3quB3L39P4X_8Gi41Dbg</recordid><startdate>20160308</startdate><enddate>20160308</enddate><creator>Palframan, Matthew J</creator><creator>Alharthy, Rima D</creator><creator>Powalowska, Paulina K</creator><creator>Hayes, Christopher J</creator><scope/></search><sort><creationdate>20160308</creationdate><title>Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition</title><author>Palframan, Matthew J ; Alharthy, Rima D ; Powalowska, Paulina K ; Hayes, Christopher J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c6ob00007j3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palframan, Matthew J</creatorcontrib><creatorcontrib>Alharthy, Rima D</creatorcontrib><creatorcontrib>Powalowska, Paulina K</creatorcontrib><creatorcontrib>Hayes, Christopher J</creatorcontrib><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palframan, Matthew J</au><au>Alharthy, Rima D</au><au>Powalowska, Paulina K</au><au>Hayes, Christopher J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition</atitle><jtitle>Organic & biomolecular chemistry</jtitle><date>2016-03-08</date><risdate>2016</risdate><volume>14</volume><issue>11</issue><spage>3112</spage><epage>3119</epage><pages>3112-3119</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences
via
solid phase synthesis. UV melting experiments showed that the
TL
MO modification gives higher
T
m
values than the corresponding
TL
DNA modification.
Triazole-linked morpholino (
TL
MO) oligonucleic acids were synthesised using the Cu
I
catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction.</abstract><doi>10.1039/c6ob00007j</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2016-03, Vol.14 (11), p.3112-3119 |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Synthesis of triazole-linked morpholino oligonucleotides Cu catalysed cycloaddition |
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