A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targetsElectronic supplementary information (ESI) available: DNA sequences, gel characterization, AFM and TEM images, and fluorescence measurements. See DOI: 10.1039/c6nr05411k

We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture. A versatile system based on aptamer-functionalized DNA nanotubes for multiplex recognition and positioning.