Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6np00126b

Covering: 2001 up to the end of 2016 Polyphenols comprise a structurally diverse class of natural products. As the development of new anthelmintic drugs against soil-transmitted helminthiases is an urgent need and polyphenols are widely used in the treatment of nematode infections in traditional medicine and modern science, we summarize the state of knowledge in the period of mainly 2001 up to the end of 2016 on plant extracts with known polyphenolic composition and of defined polyphenols, mainly from the classes of condensed and hydrolysable tannins, flavonoids, and phenylpropanoids. The diverse biological activity against different helminths and the underlying mechanisms are reviewed. A review of knowledge on plant extracts with known polyphenolic composition and of defined polyphenols against intestinal nematodes, focussing on polyphenols mainly from condensed and hydrolysable tannins, flavonoids and phenylpropanoids and their diverse biological activity against different helminths including the underlying mechanisms.