Synthesis, characterization, optical and electrochemical properties and antifungal and anticancer activities of ferrocenyl conjugated novel dendrimersElectronic supplementary information (ESI) available. See DOI: 10.1039/c6nj01120a

A new class of triazoloferrocenyl conjugates ( 1 , 2 and 3 ) was obtained by copper( i ) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjug...

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Hauptverfasser: Saravanan, Velautham, Kannan, Ayyavoo, Rajakumar, Perumal
Format: Artikel
Sprache:eng
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Zusammenfassung:A new class of triazoloferrocenyl conjugates ( 1 , 2 and 3 ) was obtained by copper( i ) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjugates 1 , 2 and 3 exhibit antifungal activity against fungal pathogens, viz. Candida albicans , Candida glabrata and Candida crusi , comparable to that of amphotericin B and also show excellent anticancer activity against MCF-7 cell lines. A new class of triazoloferrocenyl conjugates was prepared by copper( i ) catalyzed click chemistry, which shows good antifungal activity against fungal pathogens, and also shows excellent anticancer activity against MCF-7 cells.
ISSN:1144-0546
1369-9261
DOI:10.1039/c6nj01120a