Synthesis, characterization, optical and electrochemical properties and antifungal and anticancer activities of ferrocenyl conjugated novel dendrimersElectronic supplementary information (ESI) available. See DOI: 10.1039/c6nj01120a
A new class of triazoloferrocenyl conjugates ( 1 , 2 and 3 ) was obtained by copper( i ) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjug...
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Sprache: | eng |
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Zusammenfassung: | A new class of triazoloferrocenyl conjugates (
1
,
2
and
3
) was obtained by copper(
i
) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjugates
1
,
2
and
3
exhibit antifungal activity against fungal pathogens,
viz. Candida albicans
,
Candida glabrata
and
Candida crusi
, comparable to that of amphotericin B and also show excellent anticancer activity against MCF-7 cell lines.
A new class of triazoloferrocenyl conjugates was prepared by copper(
i
) catalyzed click chemistry, which shows good antifungal activity against fungal pathogens, and also shows excellent anticancer activity against MCF-7 cells. |
---|---|
ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/c6nj01120a |