Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alterationThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00461j

Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alterationThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00461j

Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu 2+ or Zn 2+ , altering the metallostasis of cancer cells, leading to their death....

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Hauptverfasser: Accardo, Antonella, Del Zoppo, Luisa, Morelli, Giancarlo, Condorelli, Daniele F, Barresi, Vincenza, Musso, Nicolò, Spampinato, Giorgia, Bellia, Francesco, Tabbì, Giovanni, Rizzarelli, Enrico
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Sprache:eng
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Zusammenfassung:Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu 2+ or Zn 2+ , altering the metallostasis of cancer cells, leading to their death. Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized.
ISSN:2040-2503
2040-2511
DOI:10.1039/c6md00461j