Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfersElectronic supplementary information (ESI) available: Experimental procedures, characterization data and copies of 1H and 13C NMR spectra. See DOI: 10.1039/c6cc08891k

Direct synthesis of NH-sulfoximines from sulfides has been achieved through O and NH transfer in the same reaction, occurring with complete selectivity. The reaction is mediated by bisacetoxyiodobenzene under simple conditions and employs inexpensive N-sources. Preliminary studies indicate that NH-transfer is likely to be first, followed by oxidation, but the reaction proceeds successfully in either order. A wide range of functional groups and biologically relevant compounds are tolerated. The use of AcO 15 NH 4 affords 15 N-labeled compounds. Direct synthesis of NH-sulfoximines from sulfides has been achieved through O and NH transfer in the same reaction, occurring with complete selectivity.