A highly selective fluorogenic probe for the detection and imaging of Cu/Zn superoxide dismutase

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn S...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-07, Vol.52 (58), p.993-996
Hauptverfasser:	Zhang, Liyun, Er, Jun Cheng, Jiang, Hao, Li, Xin, Luo, Zhaofeng, Ramezani, Thomas, Feng, Yi, Tang, Mui Kee, Chang, Young-Tae, Vendrell, Marc
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Zusammenfassung:	Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders. Fine-tuning the BODIPY chemical structure to develop a highly selective fluorophore for Cu/Zn SOD.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc00095a