Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c6bm00918b

Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c6bm00918b

Novel "zwitterionic" gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)- b -poly(lipoic methacrylate) (pMPC- b -pLA)}. In vi...

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Hauptverfasser: Jiang, Huangyong, Chen, Dong, Guo, Dongbo, Wang, Nan, Su, Yue, Jin, Xin, Tong, Gangsheng, Zhu, Xinyuan
Format: Artikel
Sprache:eng
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Zusammenfassung:Novel "zwitterionic" gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)- b -poly(lipoic methacrylate) (pMPC- b -pLA)}. In vitro , they exhibited low dark cytotoxicity and a high therapeutic efficacy to cancer cells. Their blood circulation half-life in vivo ( t 1/2 , ∼10 h) was 20-fold longer than that of CTAB-Au NRs ( t 1/2 ,
ISSN:2047-4830
2047-4849
DOI:10.1039/c6bm00918b