Graphene oxide/DNA-decorated electrode for the fabrication of microRNA biosensor

Graphene oxide/DNA-decorated electrode for the fabrication of microRNA biosensor

We fabricate a sensitive biosensor for miRNA quantification using a graphene oxide/DNA-decorated electrode. AgNPs are modified on DNA probe, which is the complementary sequence of target miRNA. Since the hybridization between DNA and miRNA releases DNA, electrochemical signals from AgNPs are decline...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:RSC advances 2015-08, Vol.5 (85), p.69334-69338
Hauptverfasser: Sun, Erlin, Wang, Lining, Zhou, Xiaodong, Ma, Chengquan, Sun, Yan, Lei, Mingde, Lu, Bingxin, Han, Ruifa
Format: Artikel
Sprache:eng
Schlagworte:
Biosensors
Deoxyribonucleic acid
Electrodes
Gene sequencing
Graphene
Oxides
Ribonucleic acids
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We fabricate a sensitive biosensor for miRNA quantification using a graphene oxide/DNA-decorated electrode. AgNPs are modified on DNA probe, which is the complementary sequence of target miRNA. Since the hybridization between DNA and miRNA releases DNA, electrochemical signals from AgNPs are declined, which indicates the concentration of miRNA. A sensitive biosensor for miRNA quantification was fabricated by using a graphene oxide/DNA-decorated electrode.
ISSN:2046-2069
DOI:10.1039/c5ra12373a