Facilely tuning the bioactivity of an orthopedic implant surface based on nanostructured polypyrrole/glycosaminoglycansElectronic supplementary information (ESI) available: Experimental details; SEM images, plots of diameter distribution and SWCA images of the NPPy/GAGs; a schematic illustration of the fabrication of NPPy/GAGs; XPS patterns of NPPy/GAGs; SEM image of NPPy/KS in a cross-sectional view; cyclic voltammogram of NPPy/KS; the plots of SWCA of NPPy/DS and NPPy/CS versus the application

Herein, we report a facile approach to tune the bioactivity of orthopedic implants. The wettability of a Ti-6Al-4V orthopedic implant surface based on nanostructured polypyrrole (NPPy) doped with glycosaminoglycans (GAGs, major extracellular matrix components) can be controlled by in situ electrical stimulus, which was utilized to tune their bioactivity. The wettability of nanostructured polypyrrole/glycosaminoglycans can be controlled in situ by electrical stimulus to tune the bioactivity of implants.