Bovine serum albumin-cobalt(ii) Schiff base complex hybrid: an efficient artificial metalloenzyme for enantioselective sulfoxidation using hydrogen peroxideElectronic supplementary information (ESI) available. CCDC 1437175. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5dt04507j

An artificial metalloenzyme (BSA-CoL) based on the incorporation of a cobalt( ii ) Schiff base complex {CoL, H 2 L = 2,2′-[(1,2-ethanediyl)bis(nitrilopropylidyne)]bisphenol} with bovine serum albumin (BSA) has been synthesized and characterized. Attention is focused on the catalytic activity of this artificial metalloenzyme for enantioselective oxidation of a variety of sulfides with H 2 O 2 . The influences of parameters such as pH, temperature, and the concentration of catalyst and oxidant on thioanisole as a model are investigated. Under optimum conditions, BSA-CoL as a hybrid biocatalyst is efficient for the enantioselective oxidation of a series of sulfides, producing the corresponding sulfoxides with excellent conversion (up to 100%), chemoselectivity (up to 100%) and good enantiomeric purity (up to 87% ee) in certain cases. An artificial metalloenzyme (BSA-CoL) based on the incorporation of a cobalt( ii ) Schiff base complex {CoL, H 2 L = 2,2′-[(1,2-ethanediyl)bis(nitrilopropylidyne)]bisphenol} with bovine serum albumin (BSA) has been synthesized and characterized.