New ruthenium(ii) coordination compounds possessing bidentate aminomethylphosphane ligands: synthesis, characterization and preliminary biological study in vitroElectronic supplementary information (ESI) available: Spectroscopic (IR, NMR) and crystal data. CCDC 1052556 (1A), 1052545 (2A), 1052557 (3A), 1052546 (2B) and 1052562 (3B). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5dt01119a

Addition of aminomethylphosphane P{CH 2 N(CH 2 CH 2 ) 2 O} 3 ( 1 ), PPh 2 {CH 2 N(CH 2 CH 2 ) 2 O} ( 2 ) or PPh 2 {CH 2 N(CH 2 CH 2 ) 2 NCH 2 CH 3 } ( 3 ) to a methanolic solution of RuCl 3 results in reduction of ruthenium( iii ) ions giving finally ttt -[RuCl 2 ( 1 ) 2 ] ( 1A ), ttt -[RuCl 2 ( 2 ) 2 ] ( 2A ) and ttt -[RuCl 2 ( 3 ) 2 ] ( 3A ). The synthesized complexes are the first examples of ruthenium( ii ) coordination compounds possessing aminomethylphosphanes chelating via phosphorus and nitrogen atoms. They were fully characterized (NMR, ESI-MS, IR, elemental analysis, X-ray crystallography). Preliminary studies of the in vitro cytotoxicity on the A549 cell line (human lung adenocarcinoma) and interactions with human serum proteins (albumin and apotransferrin) showed moderate activity of the complexes. Interestingly, the P,N-chelation leads to formation of strained 4-membered Ru-P-C-N-Ru rings, which in the case of 2A and 3A undergo opening in the presence of CH 3 CN, which results in rearrangement to ctc -[RuCl 2 ( 2 ) 2 (CH 3 CN) 2 ] ( 2B ) and ctc -[RuCl 2 ( 3 ) 2 (CH 3 CN) 2 ] ( 3B ). First examples of Ru( ii ) complexes possessing P,N-bidentate aminomethylphosphanes.