Click and release: fluoride cleavable linker for mild bioorthogonal separation
Herein, we present a water dispersable, magnetic nanoparticle supported "click and release" system. The cleavable linker has been synthesized by using a strain-promoted copper-free "click" reagent to establish the specific link and a fluoride cleavable silane moiety for mild clea...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (5), p.938-941 |
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| container_end_page | 941 |
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| container_issue | 5 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Schneider, Elia M Zeltner, Martin Zlateski, Vladimir Grass, Robert N Stark, Wendelin J |
| description | Herein, we present a water dispersable, magnetic nanoparticle supported "click and release" system. The cleavable linker has been synthesized by using a strain-promoted copper-free "click" reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.
A water dispersable, magnetic nanoparticle supported, bioorthogonal "click and release" system has been synthesized. |
| doi_str_mv | 10.1039/c5cc07692g |
| format | Article |
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A water dispersable, magnetic nanoparticle supported, bioorthogonal "click and release" system has been synthesized.</description><subject>Animals</subject><subject>Azides - chemistry</subject><subject>Azides - isolation & purification</subject><subject>Cattle</subject><subject>Chymotrypsin - chemistry</subject><subject>Chymotrypsin - isolation & purification</subject><subject>Chymotrypsin - metabolism</subject><subject>Cleavage</subject><subject>Click Chemistry</subject><subject>Dyes</subject><subject>Enzymes</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - isolation & purification</subject><subject>Fluorides</subject><subject>Fluorides - chemistry</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Nanostructure</subject><subject>Organic chemistry</subject><subject>Reagents</subject><subject>Silanes</subject><subject>Silanes - chemistry</subject><subject>Water - chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFPwzAQhS0EolBY2EEeEVLAie3YYUMRFKQKlg5ske1cSqgbFztB4t_j0lJGbrmnu09Pp3cInaXkOiW0uDHcGCLyIpvvoaOU5izhTL7urzUvEkEZH6HjEN5JrJTLQzTKci5ZJtgRei5taxZYdTX2YEEFuMWNHZxva8AmDj6VtoBt2y3A48Z5vGxtjXXrnO_f3Nx1yuIAK-VV37ruBB00ygY43fYxmj3cz8rHZPoyeSrvpolhRPZJJmqTUci4FIxqTTijhS6izlMlFRSZlrVMi5wZEu-kimfcUK5B6Ry0UXSMLje2K-8-Bgh9tWyDAWtVB24IVSoJYYLS6PsvKjgjBZWCR_RqgxrvQvDQVCvfLpX_qlJSrZOuSl6WP0lPInyx9R30Euod-httBM43gA9mt_17Ff0GpQCCEA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Schneider, Elia M</creator><creator>Zeltner, Martin</creator><creator>Zlateski, Vladimir</creator><creator>Grass, Robert N</creator><creator>Stark, Wendelin J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-2307-7521</orcidid><orcidid>https://orcid.org/0000-0001-6968-0823</orcidid></search><sort><creationdate>20160101</creationdate><title>Click and release: fluoride cleavable linker for mild bioorthogonal separation</title><author>Schneider, Elia M ; Zeltner, Martin ; Zlateski, Vladimir ; Grass, Robert N ; Stark, Wendelin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-27dc23e258743bb05439b974361a8ae92b8d81964c08423a525c35beab6ebca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Azides - chemistry</topic><topic>Azides - isolation & purification</topic><topic>Cattle</topic><topic>Chymotrypsin - chemistry</topic><topic>Chymotrypsin - isolation & purification</topic><topic>Chymotrypsin - metabolism</topic><topic>Cleavage</topic><topic>Click Chemistry</topic><topic>Dyes</topic><topic>Enzymes</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent Dyes - isolation & purification</topic><topic>Fluorides</topic><topic>Fluorides - chemistry</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Nanostructure</topic><topic>Organic chemistry</topic><topic>Reagents</topic><topic>Silanes</topic><topic>Silanes - chemistry</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Elia M</creatorcontrib><creatorcontrib>Zeltner, Martin</creatorcontrib><creatorcontrib>Zlateski, Vladimir</creatorcontrib><creatorcontrib>Grass, Robert N</creatorcontrib><creatorcontrib>Stark, Wendelin J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Elia M</au><au>Zeltner, Martin</au><au>Zlateski, Vladimir</au><au>Grass, Robert N</au><au>Stark, Wendelin J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Click and release: fluoride cleavable linker for mild bioorthogonal separation</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>52</volume><issue>5</issue><spage>938</spage><epage>941</epage><pages>938-941</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Herein, we present a water dispersable, magnetic nanoparticle supported "click and release" system. 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2016-01, Vol.52 (5), p.938-941 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_rsc_primary_c5cc07692g |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Azides - chemistry Azides - isolation & purification Cattle Chymotrypsin - chemistry Chymotrypsin - isolation & purification Chymotrypsin - metabolism Cleavage Click Chemistry Dyes Enzymes Fluorescent Dyes - chemistry Fluorescent Dyes - isolation & purification Fluorides Fluorides - chemistry Magnetite Nanoparticles - chemistry Nanostructure Organic chemistry Reagents Silanes Silanes - chemistry Water - chemistry |
| title | Click and release: fluoride cleavable linker for mild bioorthogonal separation |
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