Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticlesElectronic supplementary information (ESI) available: Conjugation of NPs with dyes, radiolabelling for NPs, NMR spectra, XRD, IR, zeta potential, DLS size distribution, TEM images and TGA data of NPs, fluorescent images of NPs. See DOI: 10.1039/c5cc02259b

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH) 3 -stabilised MnFe 2 O 4 or Fe 3 O 4 nanoparticles as precursors. They were readily and efficiently radiolabelled with 18 F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with 64 Cu. Radiolabelling, magnetic and fluorescent properties are incorporated in one single Fe 3 O 4 @HA nanoparticle with potential application as trimodal probes.